Physiol-11A13 Describe the determinants of work of breathing in an adult human at rest. Discuss the difference between static and dynamic compliance. Physiol-18A13 Define and describe lung compliance. Physiol-20B03 Describe the factors that affect respiratory system compliance. (also Physiol-02B10, Physiol-95B09) Mechanics of Breathing Include a brief explanation of the mechanism by which each achieves this increase. Physiol-06A10 List the physiological factors which increase respiratory rate. Physiol-15A02 Outline the role of carbon dioxide in the maintenance of ventilation. Depending on the disease condition, additional mechanisms that can contribute to an elevated physiological dead space measurement include shunt, a substantial increase in overall V'A/Q' ratio, diffusion impairment, and ventilation delivered to unperfused alveolar spaces.Physiol-21A15 Describe the respiratory response to hypoxaemia in both the awake and anaesthetised patient. For the range of physiological abnormalities associated with an increased physiological dead space measurement, increased alveolar ventilation/perfusion ratio (V'A/Q') heterogeneity has been the most important pathophysiological mechanism. ![]() Although a frequently cited explanation for an elevated dead space measurement has been the development of alveolar regions receiving no perfusion, evidence for this mechanism is lacking in both of these disease settings. An elevated physiological dead space, calculated from measurements of arterial CO2 and mixed expired CO2, has proven to be a useful clinical marker of prognosis both for patients with acute respiratory distress syndrome and for patients with severe heart failure.
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